ADHESION BARRIERS (currently in clinical trials)

From: Helen Dynda (olddad66@runestone.net)
Fri Feb 4 22:47:31 2000


I have included the * press releases* websites for each of these pharmaceutical companies. This will enable you to follow the progress of the gel adhesion barriers - which are now in clinical trials in the United States - as they seek to be approved by the FDA.

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** ALLIANCE PHARMACEUTICAL **

1.) * July 1999 - FloGel (A Liquid/Gel Under Development for the Reduction of Postsurgical Adhesions) - About FloGel - Technology Overview - The FloGel Advantage - Glossary of Terms

http://www.allp.com/FloGel/FG.HTM

2.) * October 21, 1999 - Alliance Pharmaceutical Corp. Announces Flo Gel Reduced Post-Surgical Adhesions in Pilot Clinical Trial

http://www.allp.com/press/press.exe?@91021

3.) * PRESS RELEASES - for Alliance Pharmaceutical

http://www.allp.com/press/press.exe?db=pressrel

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** ANIKA THERAPEUTICS **

1.) * August 11, 1998 - Incert Shown to Reduce Postoperative Adhesion Formation - click the date shown.

http://www.anikatherapeutics.com/newset.htm

2.) * PRESS RELEASES - for Anika Therapeutics http://www.anikatherapeutics.com/newset.htm

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** GENZYME GENERAL **

1.) * April 30, 1999 - Genzyme General Says Study is Largest to Document Complications Related to Adhesions.

http://www.genzyme.com/ir/gzsp/press/19990430.html

2.) * May 4, 1999 - New Data on Post-Surgical Adhesions and Small Bowel Obstruction Presented at Genzyme Symposium

http://www.genzyme.com/ir/gzsp/press/19990504.html

3.) * Completed Studies: Prevention of Postoperative Abdominal Adhesions by a Sodium Hyaluronate- Based Bioresorbable Membrane -- Abdominal Adhesiolysis: Inpatient Care and Expenditures in the United States in 1994. (You may need to type the entire URL on the address line of your computer.)

http://www.genzyme.com/prodserv/surgical_products/seprafilm/clinical/study.h tm

4.) * In Progress Research: A Prospective, Randomized, Multicenter, Controlled Evaluation of the Efficacy and Safety of Seprafilm Bioresorbable Membrane in the Reduction of the Incidence of Bowel Obstruction in General Surgery. (You may need to type the entire URL on the address line of your computer.)

http://www.genzyme.com/prodserv/surgical_products/seprafilm/clinical/progres s.htm

5.) * PRESS RELEASES - for Genzyme Surgical Products

http://www.genzyme.com/ir/gzsp/press/welcome.htm

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** GLIATECH **

1.) * ADCON Products - click each product for more information.

http://www.gliatech.com/pages/products/index.html

2.) * January 28, 1999 - Gliatech Announces Initiation of Pivotal ADCON-P Clinical Trial.

http://www.gliatech.com/news/newsread.cfm?ID=144

3.) * July 20, 1999 - Gliatech Announces FDA Approval to Initiate Clinical Trials of ADCON-A.

http://www.gliatech.com/news/newsread.cfm?ID=162

4.) * PRESS RELEASES - for Gliatech http://www.gliatech.com/news/news.cfm

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** LIFECORE BIOMEDICAL **

1.) * Intergel: an animation showing the surgical application of Intergel.

http://www.lifecore.com/hy/hyaluron.htm

2.) * March 8, 1999 - Lifecore Biomedical, Inc. announced today that it has completed the filing of its premarket approval (PMA) application for the Company's ferric hyaluronate product, Intergel Prevention Solution, with the submission to the FDA of the fifth and final module of that document last week.

http://www.lifecore.com/press_release/press22.htm

3.) * May 5, 1999 - Lifecore Anti-Adhesion Product PMA Accepted for Filing by FDA with Expedited Review Status.

http://www.lifecore.com/press_release/press24.htm

4.) * October 8, 1999 - Intergel Adhesion Prevention Solution PMA Review Scheduled for November 16, 1999 Advisory Panel Meeting

http://www.lifecore.com/press_release/press27.htm

5.) * October 22, 1999 - Lifecore Biomedical Announces Postponement of November 16 General and Plastic Surgery Devices Advisory Panel Meeting.

http://www.lifecore.com/press_release/press29.htm

6.) * PRESS RELEASES - for Lifecore Biomedical

http://www.lifecore.com/press_release/current.htm

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** LIFE MEDICAL SCIENCES **

1.) * Bioresorbable Polymer Technology - click "Products" for information about Life Medical Science's adhesion barriers: REPEL - REPEL-C - RESOLVE - RELIEVE

http://www.lifemed.com/

2.) * January 21, 1999 - Life Medical Sciences Initiates REPEL-CV Clinical Trials - Adhesion barrier could become routine part of heart surgery.

http://www.allencaron.com/clients/lifemed/releases/12199.htm

3.) * PRESS RELEASES - for Life Medical Sciences - click: Press Releases

http://www.lifemed.com/

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** ML LABORATORIES **

1.) * ML Laboratories - ADEPT

http://www.mllabs.co.uk/pages/report16.htm

2.) * 11-01-1999 -- ML's Adept approved for post-operative adhesions reduction -- click title for more information and scroll down.

http://www.mllabs.co.uk/pages/prmain24.htm

3.) * 11-18-1999 -- ML progresses towards US approval of Adept. Interim results of USA trials filed with FDA -- scroll down.

http://www.mllabs.co.uk/pages/prmain26.html

4.) * PRESS RELEASES - for ML Laboratories

http://www.mllabs.co.uk/pages/pr.htm

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