Re: PDR- hyaluronidase
From: Chu-Kuang Chen (chukchen@yahoo.com)
Thu May 10 20:14:43 2001
At Sun, 11 Feb 2001, jenny low wrote:
>
>Hyaluronidase
>Hyaluronidase (Wydase)
>Hyaluronidase
>(hy-al-your-ON-ih-days)
>Pregnancy Category: C Wydase (Rx)
>
>Classification: Enzyme, miscellaneous
>
>Action/Kinetics: Hydrolyzes hyaluronic acid, a constituent of connective
>tissue, which promotes the diffusion of injected liquids. The purified
>enzyme has no effect on BP, respiration, temperature, and kidney function.
>It is antigenic and repeated use may induce the formation of antibodies that
>neutralize the effect. Local infection will not spread as long as it is not
>injected into the infected area. Duration: 24-48 hr.
>
>Uses: Adjunct to promote absorption and dispersion of liquids and drugs, for
>hypodermoclysis, adjunct in urography to improve resorption of radiopaque
>agents, administration of local anesthetics. (Hyaluronidase can be added to
>primary drug solution or injected prior to administration of primary drug
>solution.)
>
>Contraindications: Do not inject into acutely infected or cancerous areas.
>
>Special Concerns: Use with caution during lactation.
>
>Side Effects: Rarely, sensitivity reactions, including urticaria and
>anaphylaxis.
>
>Overdose Management: Symptoms: Local edema or urticaria, chills, erythema,
>dizziness, N&V, tachycardia, hypotension. Treatment: Discontinue and begin
>supportive treatment immediately. Epinephrine, corticosteroids, and
>antihistamines may be required to treat symptoms.
>
>How Supplied: Injection: 150 U/mL; Powder for injection: 150 U, 1,500 U
>
>Dosage
>•SC Drug and fluid dispersion.
>Adults and older children, usual: 150 units added to the injection solution.
>SC urography.
>(When IV injection cannot be used.) With client in prone position: 75 units
>SC over each scapula, followed by contrast medium in same site.
>Hypodermoclysis.
>150 units, which facilitates absorption of 1,000 mL fluid (give at a rate no
>faster than would be used for IV infusion); pediatric, less than 3 years:
>volume of single clysis should be limited to 200 mL; premature infants,
>neonates: do not exceed 25 mL/kg/day given at a rate no greater than 2
>mL/min.
--
Hi,
I have been using Hyaluronidase for epidural lysis for a while. I was told that the Wydase (hyaluronidase) is discontinued and no longer manufactured. Have you heard about this? Is there any other enzyme can be used as the substitute?