I have wondered about the direct relationship between pain and inflammation and the formation/maturation of adhesions. I do believe that pain causes inflammation which causes the over-drive of the adhesion tissue to kick in. Depression causes chemical changes in the body that can cause water retention. Water retention causes depression and the whole cycle starts spiraling into itself. I think that there is the same kind of connection between the pain of adhesions being a direct cause of the inflammation response and its own spiral.
What I do know is that the adhesions that were cut back last Tuesday had blood supply and nerves. It is living tissue. That tissue was traumatized in surgery and is wounded. That wounded tissue is doing its best to repair itself. I have to pain what-so-ever from the surgery itself, I am not at all tender and barely bruised. My pain tolerance is very high. After three days, however, I could feel the same burning, stabbing sensations in the same place where the adhesions where a big problem. I know that it is the adhesion tissue itself trying to heal. I know that the nerves that were disturbed are inflamed and sending pain signals. I know that when blood supply is cut off from tissue that the tissue suffers and causes discomfort.
I am doing what I can to keep the inflammation response to a minimum through diet, supplements, exercise, and taking whatever anti-inflammatory that works for me in the moment. So far so good.
-----Original Message----- From: adhesions@adhesions.org [mailto:adhesions@adhesions.org] On Behalf Of Mark in Seattle Sent: Sunday, March 08, 2009 1:03 AM To: Multiple recipients of list ADHESIONS Subject: Re: The way to go!!!
At Sat, 7 Mar 2009, Donna Johansen wrote:
>
Interesting thing is that I have been on
>large doses of Celebrex for the arthritis and my adhesion problems
>seemed to be relatively minor last fall to recently.
Mark writes:
Donna,
You should know that Celebrex has been shown to "dramatically" reduce adhesion formation in mice. In January 2006, doctors in Boston reported a surprise discovery. It's been written up. You can read more here:
http://www.medicalnewstoday.com
search for 'adhesions'
Or you can look at the 'news' page on the home page of http://www.adhesions.org and search for the Crazy Glue article. It talks about Celebrex.
The strange thing is that I haven't heard anything new since 2005 about this. I wonder if anyone is looking into this discovery any further. There's nothing on the http://www.clinicalstudies.gov web-site. Maybe I just don't know where to look. I don't want to be a cynical person. So until I know different, I'm choosing to think that somebody somewhere is thinking about this.
But if the reports in mice are true and it works on humans, then maybe the celebrex you were taking for your arthritis has prevented the formation of adhesions after your surgery. If so, I'm very happy for you.
Yours,
Mark in Seattle
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